Paraganglioma Pheochromocytoma Genetic Testing Algorithm

Pheochromocytomas are paragangliomas of the adrenal medulla that generally secrete catecholamines (epinephrine, norepinephrine). They are often associated with certain hereditary syndromes, and all patients diagnosed with a pheochromocytoma should be referred for genetic testing. An initial genetic workup begins with a clinical evaluation or directed testing if a known familial variant exists.