Thiopurine Methyltransferase Testing - TPMT

Thiopurine drugs such as azathioprine (AZA), 6-mercaptopurine (6-MP), and 6-thioguanine (6-TG) are widely used in the treatment of acute lymphoblastic leukemia (ALL), autoimmune diseasesinflammatory bowel disease, and posttransplant organ rejection. Patients with abnormal thiopurine methyltransferase (TPMT) enzyme activity due to genetics and/or drug-drug interactions have an increased risk of toxicity when given thiopurines.

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Last Update: March 2018