0050364
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Herpes Simplex Virus Type 1 and/or 2 Antibodies, IgG & IgM (CSF) with Reflex to Type 1 & 2 Glycoprotein G-Specific Ab, IgG

HERPRCSF
Example Reports
Negative
Positive

Ordering Recommendation

Not recommended for herpes simplex virus (HSV) testing; lacks adequate predictive value for acute infection. Preferred testing is Herpes Simplex Virus (HSV-1/HSV-2) Subtype by PCR (2010095).

New York DOH Approval Status

This test is not New York state approved. There are no New York state-approved laboratories available and NYDOH is not accepting Non-permitted Laboratory Requests (NPL). Do not submit sample to ARUP.

Specimen Required

Patient Preparation
Collect

CSF.

Specimen Preparation

Transfer 1 mL CSF to an ARUP Standard Transport Tube. (Min: 0.5 mL)

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions

Specimen types other than CSF. Contaminated, heat-inactivated, or hemolyzed specimens.

Remarks
Stability

Ambient: 8 hours; Refrigerated: 2 weeks; Frozen: 1 year

Methodology

Semi-Quantitative Chemiluminescent Immunoassay /Semi-Quantitative Enzyme-Linked Immunosorbent Assay

Performed

Sun-Sat

Reported

1-2 days

Reference Interval

Test Number
 Components
 Reference Interval
  HSV 1 and/or 2 Antibodies IgM, CSF 0.89 IV or less
  HSV 1/2 Antibody Screen IgG, CSF 0.89 IV or less

Interpretive Data

This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.


Component
Interpretation
Herpes Simplex Virus Type 1 and/or 2 Antibodies, IgM, CSF by ELISA 0.89 IV or less; Negative. No significant level of detectable HSV IgM antibody.
0.90-1.09 IV: Equivocal. Questionable presence of IgM antibodies. Repeat testing in 10-14 days may be helpful.
1.10 IV or greater: Positive. IgM antibody to HSV detected which may indicate a current or recent infection.  However, low levels of IgM antibodies may occasionally persist for more than 12 months post infection.
Herpes Simplex Virus Type 1 and/or 2 Antibodies, IgG, CSF 0.89 IV or less: Negative - No significant level of detectable HSV IgG antibody.
0.90-1.09 IV: Equivocal - Questionable presence of IgG antibodies. Repeat testing in 10-14 days may be helpful.
1.10 IV or greater: Positive - IgG antibody to HSV detected which may indicate a current or past HSV infection.

Compliance Category

Laboratory Developed Test (LDT)

Note

If HSV 1/2 IgG, CSF is greater than or equal to 1.10 IV , then HSV 1 gG-Specific IgG, CSF and HSV 2 gG-Specific IgG, CSF will be added. Additional charges apply.

Hotline History

N/A

CPT Codes

86694 x2; if reflexed, add 86695; 86696

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Components

Component Test Code* Component Chart Name LOINC
0050394 HSV 1/2 Antibody Screen IgG, CSF 13249-8
0050408 HSV 1 and/or 2 Antibodies IgM, CSF 63432-9
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • glycoprotein type-specific reactivity
  • Herpes Simplex Antibodies, IgG IgM CSF
  • Herpes Simplex CSF
  • HSV 1, 2 IgG IgM CSF
  • HSV 1,2
  • HSV 1,2 and glycoprotein reflex
  • HSV 1,2 glycoprotein CSF
  • HSV CSF antibody
  • HSV glycoprotein G CSF
  • HSV glycoprotein G-based type-specific CSF
Herpes Simplex Virus Type 1 and/or 2 Antibodies, IgG & IgM (CSF) with Reflex to Type 1 & 2 Glycoprotein G-Specific Ab, IgG