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Disease Topics — Hemophilia A and hemophilia B are bleeding disorders caused by genetic variants in the F8 or F9 gene that result in deficiencies of factor VIII (FVIII) in hemophilia A or factor IX (FIX) in hemophilia B, respe Indications for TestingHemophilia testing is warranted in individuals with spontaneous bleeding (particularly into joints, muscles, and soft tissues) or prolonged/excessive bleeding that is suggestive of a coagulation disorder. … to X-linked inheritance. Acquired hemophilia, an autoimmune disorder, is rarer,…
Disease Topics — Primary membranous nephropathy (PMN) is a kidney-specific autoimmune disease that is caused by circulating antibodies against certain native podocyte antigens, specifically phospholipase A2 receptor (PLA2R) and thrombospondin type-1 domain-contain Indications for Testing
Testing for antibodies that may cause PMN should be considered in patients who present with idiopathic nephrotic syndrome (proteinuria >3.0 g/d, hypoalbuminemia, edema, hyperlipidemia and lipiduria, and normal … Primary membranous nephropathy (PMN) is a kidney-specific autoimmune disease…
Disease Topics — Thyrotoxicosis, a clinical state with serious adverse health consequences that results from excess thyroid hormone action in tissues, is often caused by elevated thyroid hormone concentrations. Indications for Testing
Laboratory testing for hyperthyroidism is appropriate in individuals with: … and psychiatric symptoms. Signs of Graves disease, an autoimmune cause of…
Disease Topics — Mature B-cell non-Hodgkin lymphomas (NHLs) represent a heterogeneous group of hematologic malignancies of lymphoid cells. Classification
The World Health Organization (WHO) has proposed a classification for B-cell lymphomas that integrates morphologic, immunophenotypic, genetic, and clinical features. … metabolic panel, and uric acid testing. HIV and hepatitis C virus (HCV) testing…
Disease Topics — Wilson disease (WD) is a rare inherited genetic disorder caused by variants in the ATP7B gene that result in copper accumulation in the body, particularly in the liver, brain, and eyes. Indications for Testing
Testing for WD is appropriate in patients with : … From ARUP Laboratories Topics From ARUP Consult Autoimmune Hepatitis…