0050381
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Rickettsia typhi (Typhus Fever) Antibody, IgG by IFA

TYPHU G
Example Reports
Negative
Positive

Ordering Recommendation

Confirm presence of Rickettsia typhi. Panel test (IgG and IgM) is preferred. Requires comparison of acute- to convalescent-phase serology.

New York DOH Approval Status

This test is New York state approved.

Specimen Required

Patient Preparation
Collect

Serum Separator Tube (SST).

Specimen Preparation

Separate from cells ASAP or within 2 hours of collection. Transfer 1 mL serum to an ARUP standard transport tube. (Min: 0.4 mL) Parallel testing is preferred and convalescent specimens must be received within 30 days from receipt of the acute specimens.

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions

Contaminated, hemolyzed, or severely lipemic specimens.

Remarks

Mark specimens plainly as "acute" or "convalescent."

Stability

After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)

Methodology

Semi-Quantitative Indirect Fluorescent Antibody (IFA)

Performed

Sun-Sat

Reported

1-3 days

Reference Interval

Test Number
 Components
 Reference Interval
  Typhus Fever Antibody, IgG Less than 1:64

Interpretive Data

Antibody reactivity to Rickettsia typhi antigen should be considered group-reactive for the Typhus Fever group, which includes Rickettsia prowazekii.

Seroconversion between acute and convalescent sera is considered strong evidence of recent infection. The best evidence for infection is a significant change (fourfold difference in titer) on two appropriately timed specimens, where both tests are done in the same laboratory at the same time. Acute-phase specimens are collected during the first week of illness and convalescent-phase samples are generally obtained 2-4 weeks after resolution of illness. Ideally these samples should be tested simultaneously at the same facility. If the sample submitted was collected during the acute phase of illness, submit a marked convalescent sample within 25 days for paired testing.


Component
 Unit Of Measure
 Interpretation
Typhus Fever Antibody, IgG Less than 1:64
1:64-1:128
1:256 or greater		 Negative - No significant level of IgG antibody detected.
Equivocal - Questionable presence of IgG antibody detected.  Repeat testing in 10-14 days may be helpful.
Positive - Presence of IgG antibody detected, suggestive of current or past infection.

Compliance Category

FDA

Note

Hotline History

View Hotline History

 

Hotline History

Date of Change
Test Name Change
Methodology
Performance/Reported Schedule
Specimen Requirements
Reference Interval
Interpretive Data
Note
CPT Code
Component Change
Other Interface Change
New Test
Inactive
05/15/2023
X
N/A

CPT Codes

86757

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Components

Component Test Code* Component Chart Name LOINC
0050381 Typhus Fever Antibody, IgG 5324-9
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • Murine Typhus Antibodies, IgG
  • R typhi IgG antibody
  • Typhus Fever Group IgG Antibody
Rickettsia typhi (Typhus Fever) Antibody, IgG by IFA