Ordering Recommendation

Use to optimize dosing and monitor patient adherence.

New York DOH Approval Status

This test is New York state approved.

Specimen Required

Patient Preparation

Timing of specimen collection: Predose (trough) draw at steady-state concentration.

Collect

Plain red. Also acceptable: Lavender (K2 or K3EDTA) or pink (K2EDTA).

Specimen Preparation

Separate serum or plasma from cells within 2 hours of collection. Transfer 1 mL serum or plasma to an ARUP standard transport tube. (Min: 0.5 mL)

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions

Whole blood. Gel separator tubes, light blue (citrate), or yellow (SPS or ACD solution).

Remarks
Stability

After separation from cells: Ambient: 5 days; Refrigerated: 2 weeks; Frozen: 6 months

Methodology

Quantitative Liquid Chromatography-Tandem Mass Spectrometry

Performed

Fri

Reported

2-8 days

Reference Interval

Effective February 19, 2013

Therapeutic Range Total (imipramine and desipramine): 150-300 ng/mL
Toxic Level Greater than 500 ng/mL

Interpretive Data

Toxic concentrations may cause anticholinergic effects, drowsiness, and cardiac abnormalities.

Compliance Category

Note

Report includes individual values for imipramine, desipramine, and total.

Hotline History

CPT Codes

80335 (Alt code: G0480)

Components

Component Test Code* Component Chart Name LOINC
0090065 Desipramine, SP 3531-1
0090135 Imipramine/Desipramine Total, SP 9627-1
0090139 Imipramine, SP 3690-5
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • Antideprin
  • Deprenyl
  • Surplix
  • Melepramin
  • Tofranil
  • Deprimin
  • Deprinol
  • Desipramine/Imipramine
  • Eupramin
  • Imipramil
  • Impril
  • Irmin
  • Janimine
  • Tricyclic Antidepressants
  • TCA
  • Norpramin
  • Novo-Parmine
  • Presamine
  • Imipramine and Metabolite
  • Imipramine/Desipramine Fractionation
Imipramine and Desipramine, Serum or Plasma