Ordering Recommendation

Use to optimize dosing and monitor patient adherence.

New York DOH Approval Status

This test is New York state approved.

Specimen Required

Patient Preparation

Timing of specimen collection: Predose (trough) draw at steady-state concentration.

Collect

Plain red. Also acceptable: Lavender (K2 or K3EDTA) or pink (K2EDTA).

Specimen Preparation

Separate serum or plasma from cells within 2 hours of collection. Transfer 1 mL serum or plasma to an ARUP standard transport tube. (Min: 0.5 mL)

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions

Whole blood. Gel separator tubes, light blue (citrate), or yellow (SPS or ACD solution).

Remarks
Stability

After separation from cells: Ambient: 5 days; Refrigerated: 2 weeks; Frozen: 6 months

Methodology

Quantitative Liquid Chromatography-Tandem Mass Spectrometry

Performed

Mon, Wed, Fri

Reported

1-7 days

Reference Interval

Effective February 19, 2013

Therapeutic Range Total (imipramine and desipramine): 150-300 ng/mL
Toxic Level Greater than 500 ng/mL

Interpretive Data

Toxic concentrations may cause anticholinergic effects, drowsiness, and cardiac abnormalities.

Compliance Category

Laboratory Developed Test (LDT)

Note

Report includes individual values for imipramine, desipramine, and total.

Hotline History

N/A

CPT Codes

80335 (Alt code: G0480)

Components

Component Test Code* Component Chart Name LOINC
0090065 Desipramine, SP 3531-1
0090135 Imipramine/Desipramine Total, SP 9627-1
0090139 Imipramine, SP 3690-5
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • Antideprin
  • Deprenyl
  • Deprimin
  • Deprinol
  • Desipramine/Imipramine
  • Eupramin
  • Imipramil
  • Imipramine and Metabolite
  • Imipramine/Desipramine Fractionation
  • Impril
  • Irmin
  • Janimine
  • Melepramin
  • Norpramin
  • Novo-Parmine
  • Presamine
  • Surplix
  • TCA
  • Tofranil
  • Tricyclic Antidepressants
Imipramine and Desipramine, Serum or Plasma (Test on Referral as of 03/05/24)