Hereditary Cancer Panel Comparison

Selecting the RIGHT test for the RIGHT patient is crucial but navigating various multigene panels with both overlapping and unique gene components can be time consuming. To ease this process and save time, the following table can be used to compare gene contents and testing indications for ARUP Laboratories’ hereditary cancer panels.

To compare the gene lists for specific tests or see which tests offer a specific gene, use the associated checkboxes. For specific information about a test or gene, click the test name or gene name.

Please note the following indications for genetic testing:

  • Testing minors for adult-onset conditions is not recommended; testing will not be performed in minors without prior approval. For additional information, please contact an ARUP genetic counselor at 800-242-2787 ext. 2141.
  • If a familial variant has previously been identified, testing should be performed for that specific variant using Familial Targeted Sequencing (ARUP test code 3005867) or contact an ARUP genetic counselor at 800-242-2787 ext. 2141.

 

 

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Hereditary Cancer Panel 2012032
Hereditary Breast and Gynecological Panel 2012026
Hereditary Breast Cancer Guidelines‐Based Panel 3005654
Hereditary Breast Cancer High‐Risk Panel 3005632
BRCA1 and BRCA2‐Associated HBOC Syndrome Panel 3001855
Hereditary Gastrointestinal Cancer Panel 2013449
Hereditary Gastrointestinal Cancer High‐Risk Panel 3005697
Lynch Syndrome Panel 3001605
APC‐ and MUTYH‐Associated Polyposis Panel 3004407
Hereditary Renal Cancer Panel 2010214
Hereditary Pancreatic Cancer Panel 3005708
Hereditary Prostate Cancer Panel 3005686

ALK

105590

ALK-related neuroblastic tumor susceptibility
Ganglioneuroblastoma, ganglioneuroma, neuroblastoma Inheritance: Autosomal dominant

                     

APC

611731

Familial adenomatous polyposis (FAP)
Attenuated familial adenomatous polyposis (AFAP)
Gastric adenocarcinoma and proximal polyposis of the stomach (GAPPS)
Colorectal adenomas and cancer, duodenal adenomas and cancer, gastric fundic gland polyps, medulloblastoma, osteomas, pancreatic, thyroid, and others Inheritance: Autosomal dominant

             

ATM

607585

Breast, colorectal, ovarian, pancreatic, prostate Inheritance: Autosomal dominant
Ataxia-telangiectasia Inheritance: Autosomal recessive

             

AXIN2

604025

Oligodontia-colorectal cancer syndrome (ODCRCS)
Colorectal, polyposis Inheritance: Autosomal dominant

                   

BAP1

603089

BAP1 tumor predisposition syndrome (BAP1-TPDS)
BAP1-inactivated melanocytic tumors, basal cell carcinoma, cutaneous melanoma, malignant mesothelioma, renal cell carcinoma, uveal melanoma Inheritance: Autosomal dominant

                   

BARD1

601593

Breast Inheritance: Autosomal dominant

                 

BMPR1A

601299

Juvenile polyposis syndrome (JPS)
Colorectal, juvenile polyps, small intestine, stomach Inheritance: Autosomal dominant

                   

BRCA1

113705

Hereditary breast and ovarian cancer (HBOC) syndrome
Breast, fallopian tube, ovarian, pancreatic, peritoneal, prostate Inheritance: Autosomal dominant
Fanconi anemia, complementation group S Inheritance: Autosomal recessive

         

BRCA2

600185

Hereditary breast and ovarian cancer (HBOC) syndrome
Breast, fallopian tube, melanoma, ovarian, pancreatic, peritoneal, prostate Inheritance: Autosomal dominant
Fanconi anemia, complementation group D1 Inheritance: Autosomal recessive

         

BRIP1

605882

Breast, ovarian Inheritance: Autosomal dominant
Fanconi anemia, complementation group J Inheritance: Autosomal recessive

                   

CDC73

607393

CDC73-related disorders
Hyperparathyroidism-jaw tumor syndrome
Hyperparathyroidism/parathyroid carcinoma, kidney lesions/tumors Inheritance: Autosomal dominant

                     

CDH1

192090

Hereditary diffuse gastric cancer (HDGC)
Diffuse gastric, lobular breast Inheritance: Autosomal dominant

             

CDK4

123829

Cutaneous melanoma, pancreatic Inheritance: Autosomal dominant

                   

CDKN1B

600778

Multiple endocrine neoplasia (MEN) Type 4
Gastrinoma, gastro-entero-pancreatic (GEP), nonendocrine, parathyroid, pituitary Inheritance: Autosomal dominant

                     

CDKN2A

600160

Familial atypical multiple mole melanoma-pancreatic carcinoma (FAMMM-PC) syndrome (also known as melanoma-pancreatic cancer syndrome)
Cutaneous melanoma, pancreatic Inheritance: Autosomal dominant

                   

CHEK2

604373

Breast, colorectal, prostate, thyroid Inheritance: Autosomal dominant

             

CTNNA1

116805

Breast, stomach Inheritance: Autosomal dominant

                     

DICER1

606241

DICER1-related disorders
Pleuropulmonary blastoma, ovarian sex cord-stromal tumors, cystic nephroma, thyroid Inheritance: Autosomal dominant

                 

EGFR

131550

Lung Inheritance: Autosomal dominant

                     

EPCAM

185535

Lynch syndrome/hereditary nonpolyposis colorectal cancer (HNPCC)
Brain, colorectal, endometrial, ovarian, pancreatic, prostate, renal pelvis and/or ureter, stomach, and others Inheritance: Autosomal dominant

       

FH

136850

FH tumor predisposition syndrome/hereditary leiomyomatosis and renal cell cancer (HLRCC)
Cutaneous and uterine leiomyomata, papillary type 2 renal cancer, paraganglioma, pheochromocytoma Inheritance: Autosomal dominant
Fumarase deficiency Inheritance: Autosomal recessive

                   

FLCN

607273

Birt-Hogg-Dubé syndrome (BHDS)
Fibrofolliculomas, pulmonary cysts/history of pneumothorax, renal cancer Inheritance: Autosomal dominant

                   

HOXB13

604607

Prostate Inheritance: Autosomal dominant

                   

HRAS

190020

Costello syndrome
Neuroblastoma, rhabdomyosarcoma, transitional cell carcinoma of the bladder Inheritance: Autosomal dominant

                     

KIT

164920

Gastrointestinal stromal tumor (GIST) Inheritance: Autosomal dominant

                   

LZTR1

600574

Schwannomatosis Inheritance: Autosomal dominant
Noonan syndrome Inheritance: Autosomal recessive

                     

MAX

154950

Hereditary paraganglioma-pheochromocytoma (HPP) syndromes
Paraganglioma, pheochromocytoma Inheritance: Autosomal dominant

                     

MC1R

155555

Cutaneous melanoma Inheritance: Autosomal dominant

                     

MEN1

613733

Multiple endocrine neoplasia type 1 (MEN1)
Adrenocortical, carcinoid, gastro-entero-pancreatic (GEP), neuroendocrine tumors, meningioma, parathyroid, pituitary, thyroid Inheritance: Autosomal dominant

                   

MET

164860

Hereditary papillary renal cell carcinoma (HPRCC)
Papillary type 1 renal cancer

                   

MITF

156845

Waardenburg syndrome type II
Cutaneous melanoma

                     

MLH1

120436

Lynch syndrome/hereditary nonpolyposis colorectal cancer (HNPCC)
Brain, colorectal, endometrial, ovarian, pancreas, prostate, renal pelvis and/or ureter, stomach, and others Inheritance: Autosomal dominant
Constitutional mismatch repair deficiency (CMMRD) Inheritance: Autosomal recessive

       

MLH3

120436

MLH3-associated polyposis
Breast, colorectal, polyposis Inheritance: Autosomal dominant

                   

MSH2

609309

Lynch syndrome/hereditary nonpolyposis colorectal cancer (HNPCC)
Brain, colorectal, endometrial, ovarian, pancreas, prostate, renal pelvis and/or ureter, stomach, and others Inheritance: Autosomal dominant
Constitutional mismatch repair deficiency (CMMRD) Inheritance: Autosomal recessive

       

MSH3

600887

Colorectal, polyposis Inheritance: Autosomal dominant

                   

MSH6

600678

Lynch syndrome/hereditary nonpolyposis colorectal cancer (HNPCC)
Brain, colorectal, endometrial, ovarian, pancreas, prostate, renal pelvis and/or ureter, stomach, and others Inheritance: Autosomal dominant
Constitutional mismatch repair deficiency (CMMRD) Inheritance: Autosomal recessive

       

MUTYH

604933

Breast, colorectal Inheritance: Autosomal dominant
MUTYH-associated polyposis (MAP)
Colorectal adenomas and cancer, duodenal adenomas and cancer Inheritance: Autosomal recessive

               

NBN

602667

Breast, ovarian, prostate Inheritance: Autosomal dominant
Nijmegan breakage syndrome (NBS) Inheritance: Autosomal recessive

                 

NF1

613113

Neurofibromatosis type 1 (NF1)
Breast, gastrointestinal stromal tumor (GIST), gliomas, leukemia, malignant peripheral nerve sheath tumors, neurofibromas, pheochromocytoma Inheritance: Autosomal dominant

                 

NF2

607379

Neurofibromatosis type 2 (NF2)
Astrocytoma, ependymoma, meningioma, schwannoma Inheritance: Autosomal dominant

                     

NTHL1

602656

Colorectal, polyposis Inheritance: Autosomal recessive

                   

PALB2

610355

Breast, ovarian, pancreas, prostate Inheritance: Autosomal dominant
Fanconi anemia, complementation group N Inheritance: Autosomal recessive

           

PDGFRA

173490

Gastrointestinal stromal tumor (GIST), inflammatory fibroid polyp, fibroid tumor Inheritance: Autosomal dominant

                   

PMS2

600259

Lynch syndrome/hereditary nonpolyposis colorectal cancer (HNPCC)
Brain, colorectal, endometrial, ovarian, pancreas, prostate, renal pelvis and/or ureter, stomach, and others Inheritance: Autosomal dominant
Constitutional mismatch repair deficiency (CMMRD) Inheritance: Autosomal recessive

       

POLD1

174761

Polymerase proofreading-associated polyposis (PPAP)
Colorectal, polyposis Inheritance: Autosomal dominant

                   

POLE

174762

Polymerase proofreading-associated polyposis (PPAP)
Colorectal, polyposis Inheritance: Autosomal dominant

                   

POT1

606478

POT1 tumor predisposition syndrome
Angiosarcoma, chronic lymphocytic leukemia, cutaneous melanoma, glioma Inheritance: Autosomal dominant

                     

PRKAR1A

188830

Carney complex
Endocrine tumor or overactivity, myxoma, schwannoma Inheritance: Autosomal dominant

                     

PTCH1

601309

Nevoid basal cell carcinoma syndrome (NBCCS)/Gorlin syndrome
Basal cell carcinoma, cardiac and ovarian fibromas, medulloblastoma Inheritance: Autosomal dominant

                     

PTEN

601728

Cowden syndrome/PTEN hamartoma tumor syndrome
Breast, colorectal, endometrial, Lhermitte-Duclos disease (cerebellar dysplastic gangliocytoma), melanoma a, renal cell carcinoma, thyroid, and others Inheritance: Autosomal dominant

           

RAD51C

602774

Breast, ovarian Inheritance: Autosomal dominant
Fanconi anemia, complementation group O Inheritance: Autosomal recessive

                   

RAD51D

602954

Breast, ovarian, prostate Inheritance: Autosomal dominant

                 

RB1

614041

Hereditary retinoblastoma
Melanoma, osteosarcoma, pinealoblastoma, retinoblastoma, retinoma, soft tissue sarcoma Inheritance: Autosomal dominant

                     

RECQL

600537

Breast Inheritance: Autosomal dominant

                   

RET

164761

Multiple endocrine neoplasia 2 (MEN2)
Medullary thyroid carcinoma, parathyroid adenoma or hyperplasia, pheochromocytoma Inheritance: Autosomal dominant

                     

SDHA

600857

Hereditary paraganglioma-pheochromocytoma (HPP) syndromes
Gastrointestinal stromal tumor (GIST), paraganglioma, pheochromocytoma, pulmonary chondroma, renal clear cell carcinoma

                 

SDHAF2

613019

Hereditary paraganglioma-pheochromocytoma (HPP) syndromes
Paraganglioma Inheritance: Autosomal dominant

                     

SDHB

185470

Hereditary paraganglioma-pheochromocytoma (HPP) syndromes
Gastrointestinal stromal tumor (GIST), paraganglioma, pheochromocytoma, pulmonary chondroma, renal clear cell carcinoma Inheritance: Autosomal dominant

                 

SDHC

602413

Hereditary paraganglioma-pheochromocytoma (HPP) syndromes
Gastrointestinal stromal tumor (GIST), paraganglioma, pheochromocytoma, pulmonary chondroma, renal clear cell carcinoma Inheritance: Autosomal dominant

                 

SDHD

602690

Hereditary paraganglioma-pheochromocytoma (HPP) syndromes
Gastrointestinal stromal tumor (GIST), paraganglioma, pheochromocytoma, pulmonary chondroma, renal clear cell carcinoma Inheritance: Autosomal dominant

                 

SMAD4

600993

Juvenile polyposis syndrome (JPS), hereditary hemorrhagic telangiectasia (HHT) syndrome
Colorectal, juvenile polyps, small intestine, stomach Inheritance: Autosomal dominant

                   

SMARCA4

603254

Coffin-Siris syndrome, rhabdoid tumor predisposition syndrome (RTPS)
Rhabdoid tumors located in CNS, kidney, ovary (small cell carcinoma of the ovary hypercalcemic type [SCCOHT]), and others Inheritance: Autosomal dominant

                 

SMARCB1

601607

Coffin-Siris syndrome, rhabdoid tumor predisposition syndrome (RTPS)
Associated cancer(s)/tumor(s): Associated cancer(s)/tumor(s): rhabdoid tumors located in: CNS, kidney, and others; schwannomatosis Inheritance: Autosomal dominant

                   

SMARCE1

603111

Coffin-Siris syndrome
Meningioma Inheritance: Autosomal dominant

                     

STK11

602216

Peutz-Jeghers syndrome (PJS)
Breast, cervix, colorectal, endometrial, lung, ovarian (sex cord with annular tubules), pancreas, Peutz-Jeghers-type hamartomatous polyps, small intestine, stomach, testes Inheritance: Autosomal dominant

             

SUFU

607035

Nevoid basal cell carcinoma syndrome (NBCCS)/Gorlin syndrome
Basal cell carcinoma, cardiac and ovarian fibromas, medulloblastoma Inheritance: Autosomal dominant

                     

TERT

187270

Dyskeratosis congenita
Acute myelogenous leukemia, melanoma, pulmonary fibrosis Inheritance: Autosomal dominant and autosomal recessive

                     

TMEM127

613403

Hereditary paraganglioma-pheochromocytoma (HPP) syndromes
Paraganglioma, pheochromocytoma, renal clear cell carcinoma Inheritance: Autosomal dominant

                     

TP53

191170

Li-Fraumeni syndrome (LFS)
Adrenocortical carcinoma, breast, choroid plexus carcinoma, CNS, colorectal, melanoma, osteosarcoma, pancreas, prostate, renal, rhabdomyosarcoma, soft tissue sarcoma, stomach, thyroid, and others Inheritance: Autosomal dominant

       

TSC1

605284

Tuberous sclerosis complex (TSC)
Cardiac rhabdomyoma, fibromas, renal angiomyolipoma, retinal and other hamartomas, subependymal giant cell astrocytoma (SEGA), and others Inheritance: Autosomal dominant

                   

TSC2

191092

Tuberous sclerosis complex (TSC)
Cardiac rhabdomyoma, fibromas, renal angiomyolipoma, retinal and other hamartomas, subependymal giant cell astrocytoma (SEGA), and others Inheritance: Autosomal dominant

                   

VHL

608537

Von Hippel-Lindau (VHL) syndrome
Endolymphatic sac tumors, epididymal and broad ligament cystadenomas, hemangioblastoma, neuroendocrine tumors, pheochromocytoma, renal cell carcinoma, retinal angioma Inheritance: Autosomal dominant

                 

WT1

607102

WT1 disorder
Gonadoblastoma, Wilms tumor Inheritance: Autosomal dominant

                     
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