Leukocyte adhesion deficiency (LAD) disorders are primary immune deficiency syndromes that affect the leukocyte adhesion process. There are three types of LAD – 1, 2, and 3. LAD1 is the most common type.
Quick Answers for Clinicians
ARUP Lab Tests
Use to diagnose type I and II leukocyte adhesion deficiency syndromes
Panel includes CD11b, CD15, CD18
Initial testing to identify abnormalities in neutrophils
Automated Cell Count/Differential
Evaluate patients with suspected inherited qualitative platelet disorders or patients with lifelong platelet-type bleeding
Studies include platelet aggregation studies, ADP; collagen; AA; ristocetin
Al-Herz W, Bousfiha A, Casanova JL, et al. Primary immunodeficiency diseases: an update on the classification from the International Union of Immunological Societies expert committee for primary immunodeficiency. Front Immunol. 2014; 5:162.