Takayasu arteritis is a form of granulomatous arteritis that primarily affects the aorta and its major branches. It is most prevalent in adolescent girls and young women and is characterized by ocular disturbances and marked weakening of the pulses in the upper extremities. It is categorized as a large-vessel vasculitis (Jennette, 2013).
Quick Answers for Clinicians
ARUP Lab Tests
Preferred test to detect acute phase inflammation (eg, autoimmune diseases, connective tissue disease, rheumatoid arthritis, infection, or sepsis)
Preferred reflex panel for managing patients with known diagnosis of vasculitis; may assist in evaluating suspected vasculitis
For the workup of suspected vasculitis, preferred panel is ANCA-associated vasculitis profile (ANCA/MPO/PR3) with reflex to ANCA titer
Semi-Quantitative Indirect Fluorescent Antibody/Semi-Quantitative Multiplex Bead Assay
Panel includes ANCA (IgG), myeloperoxidase antibody, and serine proteinase 3 antibody
Reflex pattern: if screen is positive, then titer and MPO/PR3 antibodies testing will be added to aid in antibody determination
Screen for various metabolic and kidney disorders
May help in ruling out infectious process
Automated Cell Count/Differential
Nonspecific test used to detect inflammation associated with infections, cancers, and autoimmune diseases
Jennette JC, Falk RJ, Bacon PA, et al. 2012 revised International Chapel Hill Consensus Conference nomenclature of vasculitides. Arthritis Rheum. 2013;65(1):1-11.