Antiphospholipid Syndrome Testing Algorithm

Antiphospholipid syndrome (APS) is an autoimmune disorder characterized by vascular thrombosis, pregnancy complications and persistently positive tests for antiphospholipid protein (aPL) antibodies. An initial workup includes testing for antibodies common to antiphospholipid syndrome, including lupus anticoagulant (LA) activity, cardiolipin (aCL) antibodies, and beta-2 glycoprotein 1 antibodies.