Antiphospholipid Syndrome - APS

Antiphospholipid syndrome (APS), also called antiphospholipid antibody syndrome, is an autoimmune disorder in which autoantibodies are directed against phospholipid-protein complexes. APS is characterized by thromboses (arterial, venous, or small vessel) and/or pregnancy complications and persistently positive tests for antiphospholipid-protein (aPL) antibodies.   Cytopenias or other hematologic disorders, and neurologic, dermatologic, or cardiopulmonary abnormalities, may also be seen in patients with APS.   Catastrophic APS is an uncommon acute form of the syndrome that results in extensive thrombotic microangiopathy and multiorgan failure.  Those at increased risk for APS include patients with systemic lupus erythematosus (SLE), infections, malignancy, and liver or vascular disease. Some medications are also associated with increased risk. Transient aPL antibodies may occur in association with infections, certain medications (procainamide, chlorpromazine), and malignancy. 

Tabs Content
Content Review: 
August 2018

Last Update: November 2018