Syphilis Testing Algorithm

Testing for Treponema pallidum, the causative agent for syphilis, can be performed using either the traditional method or the reverse sequence screening method. An initial workup for syphilis includes either a nontreponemal screening assay followed by a confirmatory treponemal test (traditional sequence), or an automated treponemal test followed by a confirmatory nontreponemal test (reverse sequence). In the reverse sequence, discordant results must be confirmed by another treponemal test.

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