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Respiratory Pathogen Molecular Panel Testing

0060764

Respiratory Virus Mini Panel by PCR 0060764

Method

Qualitative Reverse Transcription Polymerase Chain Reaction

Preferred test to confirm respiratory syncytial virus (RSV), influenza A, or influenza B in general inpatients and RSV in adults.

3001479

Respiratory Viral Panel by PCR 3001479

Method

Qualitative Polymerase Chain Reaction

Preferred test for evaluating severely immunocompromised (eg, BMT) or critically ill (ICU) patients with respiratory symptoms.
Test detects influenza A, influenza B, RSV, human metapneumovirus, human rhinovirus, and adenovirus.
Detects and differentiates parainfluenza 1, 2, 3, and 4.

Viral respiratory tract infections are the most common diseases affecting humans worldwide. Respiratory viruses can be associated with both self-limiting upper respiratory tract infections (eg, the common cold) and more severe lower respiratory tract infections (LRTIs) (eg, bronchitis, bronchiolitis, pneumonitis, pneumonia). LRTIs are a major cause of hospitalization, morbidity, and mortality in infants and the elderly and are associated with significant disease burden.

Disease Overview

Incidence

Viral infections cause approximately 80% of respiratory tract disease; mixed infections account for approximately 20% infection in adults, 60% in children
Symptomatic disease varies by viral type and patient age
- Highest rates occur in young and elderly populations with widely varying outcomes
Seasonal influenza causes a large proportion of viral respiratory disease
- Median incidence of approximately 8% in U.S. 2010 to 2016

Symptoms

Symptoms general occur within 1-3 days of exposure and last 7-14 days.

Location	Symptoms
Upper respiratory infections	Nasal congestion Sneezing Cough Sore throat Fever Chills Fatigue Decreased appetite^a Lethargy^a
Lower respiratory infections^b	Worsening cough Shortness of breath Focal pain Dizziness^c Confusion^c
^aEspecially in children ^bOverlap with upper infection ^cOlder adults

Location

Symptoms

Upper respiratory infections

Nasal congestion

Sneezing

Cough

Sore throat

Fever

Chills

Fatigue

Decreased appetite^a

Lethargy^a

Lower respiratory infections^b

Worsening cough

Shortness of breath

Focal pain

Dizziness^c

Confusion^c

^aEspecially in children

^bOverlap with upper infection

^cOlder adults

Test Interpretation

Limitations

Negative result

Does not rule out the presence of polymerase chain reaction (PCR) inhibitors in patient specimen
Does not detect assay-specific nucleic acid in concentrations below level of detection by assay

Feedback

Respiratory Pathogen Molecular Panel Testing

Disease Overview

Incidence

Symptoms

Test Interpretation

Limitations