Respiratory Pathogen Molecular Panel Testing
Preferred test to confirm respiratory syncytial virus (RSV), influenza A, or influenza B in general inpatients and RSV in adults.
Preferred test for evaluating severely immunocompromised (eg, BMT) or critically ill (ICU) patients with respiratory symptoms.
Test detects influenza A, influenza B, RSV, human metapneumovirus, human rhinovirus, and adenovirus.
Detects and differentiates parainfluenza 1, 2, 3, and 4.
Follow-up test for patients with documented influenza A.
Not a first-line test for the detection of suspected influenza in most clinical situations.
Detect and subtype the two predominant strains of circulating influenza A (H1N1 and H3N2).
Viral respiratory tract infections are the most common diseases affecting humans worldwide. Respiratory viruses can be associated with both self-limiting upper respiratory tract infections (eg, the common cold) and more severe lower respiratory tract infections (LRTIs) (eg, bronchitis, bronchiolitis, pneumonitis, pneumonia). LRTIs are a major cause of hospitalization, morbidity, and mortality in infants and the elderly and are associated with significant disease burden.
- Viral infections cause ~80% of respiratory tract disease; mixed infections account for ~20 percent infection in adults, 60% in children
- Symptomatic disease varies by viral type and patient age
- Highest rates occur in young and elderly populations with widely varying outcomes
- Seasonal influenza causes a large proportion of viral respiratory disease
- Median incidence of ~8% in U.S. 2010 to 2016
Symptoms general occur within 1-3 days of exposure and last 7-14 days.
|Upper respiratory infections||
|Lower respiratory infectionsb||
Shortness of breath
aEspecially in children
bOverlap with upper infection
- Does not rule out the presence of polymerase chain reaction (PCR) inhibitors in patient specimen
- Does not detect assay-specific nucleic acid in concentrations below level of detection by assay
- Self WH, Williams DJ, Zhu Y, Ampofo K, Pavia AT, Chappell JD, Hymas WC, Stockmann C, Bramley AM, Schneider E, Erdman D, Finelli L, Jain S, Edwards KM, Grijalva CG. Respiratory Viral Detection in Children and Adults: Comparing Asymptomatic Controls and Patients With Community-Acquired Pneumonia. J Infect Dis. 2016; 213(4): 584-91. PubMed
- Jain S, Williams DJ, Arnold SR, Ampofo K, Bramley AM, Reed C, Stockmann C, Anderson EJ, Grijalva CG, Self WH, Zhu Y, Patel A, Hymas W, Chappell JD, Kaufman RA, Kan H, Dansie D, Lenny N, Hillyard DR, Haynes LM, Levine M, Lindstrom S, Winchell JM, Katz JM, Erdman D, Schneider E, Hicks LA, Wunderink RG, Edwards KM, Pavia AT, McCullers JA, Finelli L, CDC EPIC Study Team. Community-acquired pneumonia requiring hospitalization among U.S. children. N Engl J Med. 2015; 372(9): 835-45. PubMed
- Tokars JI, Olsen SJ, Reed C. Seasonal Incidence of Symptomatic Influenza in the United States. Clin Infect Dis. 2018; 66(10): 1511-1518. PubMed
Last Update: May 2019