Eosinophil-Related Disorders - Eosinophilia

Eosinophilia is an expansion of eosinophil numbers in the blood, due to either a reactive process, such as an allergic reaction or parasitic infection (secondary eosinophilia), or to a neoplastic process that involves clonal eosinophils or their precursors (primary eosinophilia).   The eosinophil has potent proinflammatory, prothrombotic, and profibrotic activities. Eosinophilia can accompany a range of disorders from benign diseases, to eosinophilias with organ damage, to eosinophil neoplasms. Given the broad array of diseases associated with eosinophilia, a variety of presentations may prompt testing.   The extent of peripheral blood eosinophilia (>500 or >1,500 cells/µL) and the impact of eosinophilia on major organs should be evaluated.   Identifying the etiology is essential for treatment decisions, and treating the underlying disorder often will resolve the eosinophilia.  In addition to the laboratory tests described below, histopathologic analysis of a tissue biopsy from a relevant site and/or a bone marrow biopsy may be necessary for diagnosis.

Tabs Content
Content Review: 
October 2019

Last Update: November 2019