Gastrointestinal Stromal Tumors - GISTs

Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the gastrointestinal (GI) tract, representing ~20% of all sarcomas. Common mutations occurring in KIT and PGFRA, which are both highly expressed in these tumors, result in constitutive tyrosine kinase activity and make the tumors sensitive to tyrosine kinase inhibitors (TKIs), with some exceptions.

Tabs Content
Content Review: 
June 2017

Last Update: October 2018