Primary Membranous Nephropathy - Idiopathic Membranous Glomerulonephritis

Membranous nephropathy (MN) is one of the common causes of nephrotic-range proteinuria. Affected patients present with peripheral edema, decreased serum albumin, and often hyperlipidemia (Kodner, 2016). Secondary causes of MN include drugs, autoimmune disease, infections, and malignancy (Kidney Disease: Improving Global Outcomes [KDIGO], 2012). Once these are ruled out, the remaining cases (approximately 75%) are considered primary or idiopathic. Renal biopsy is the gold standard for diagnosis of membranous nephropathy. Testing for phospholipase A2 receptor (PLA2R) antibody can assist with the differentiation of primary and secondary membranous nephropathy.

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Last Update: October 2019