Antiglomerular Basement Membrane Disease - Goodpasture Syndrome

Antiglomerular basement membrane (anti-GBM) disease (Goodpasture syndrome) is an autoimmune condition characterized by progressive damage to collagen, resulting in damage to the lung parenchyma and the kidney basement membrane. Lung damage results in hemorrhage with cough and shortness of breath. Deposits in the kidneys result in glomerulonephritis and renal disease. The symptoms can progress over time or be rapidly progressive. Anti-GBM is categorized as a small-vessel vasculitis (Chapel Hill, 2012).

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Last Update: March 2018