Antiglomerular Basement Membrane Disease - Goodpasture Syndrome

Antiglomerular basement membrane (anti-GBM) disease (often referred to as Goodpasture syndrome or Goodpasture disease, depending on presentation) is a rare autoimmune condition characterized by damage to capillaries of the kidneys and lungs due to the deposition of pathogenic anti-GBM autoantibodies.    More than 80% of patients with anti-GBM disease will present with features of rapidly progressive glomerulonephritis and renal disease, and up to 60% will have evidence of lung hemorrhage.  Early intervention has a significant effect on organ survival; rapid diagnosis and initiation of treatment is therefore essential.   Laboratory testing in anti-GBM disease includes serologic (antibody) testing, deposited antibody testing, and renal histopathology for diagnosis, as well as testing for organ dysfunction and monitoring for treatment efficacy.

Tabs Content
Content Review: 
May 2019

Last Update: May 2019