Topic Name

Message

If ARUP Consult does not answer your test selection and interpretation questions, or if you would like to suggest ways to improve content or usability, please send a message to the Consult editorial staff.

Please do not include any patient-specific or personal health information (PHI) in your message.

Email Address

An email address is not required, but providing one allows the ARUP Consult editorial staff to respond directly. ARUP will only use your email address to respond to your feedback. See the ARUP privacy policy for more information regarding email use.

CAPTCHA

What code is in the image?

Enter the characters shown in the image.

This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.

Antiphospholipid Syndrome Reflex Panel

3017157

Antiphospholipid Syndrome Reflex Panel 3017157

Method

Electromagnetic Mechanical Clot Detection/Chromogenic Assay/Semi-Quantitative Enzyme-Linked Immunosorbent Assay (ELISA)

This test is the preferred initial panel for the evaluation of suspected antiphospholipid syndrome. This reflex panel provides a multistep combination of assays.

Test Description

Test Components and Reflex Patterns

When the Antiphospholipid Syndrome Reflex Panel is ordered, three initial tests will always be ordered and performed by ARUP. These tests are also available separately.

Tests Always Performed as Part of the Antiphospholipid Syndrome Reflex Panel (3017157)
Test	Method	Standalone Test Code
Beta-2 Glycoprotein 1 Antibodies, IgG and IgM	Semi-quantitative enzyme-linked immunosorbent assay	0050321
Cardiolipin Antibodies, IgG and IgM	Semi-quantitative enzyme-linked immunosorbent assay	0099344
Lupus Anticoagulant Reflex Panel	Electromagnetic mechanical clot detection/chromogenic assay	3017009

Based on the results of the above assays, the following tests may be performed by reflex (additional charges apply):

Tests That May Be Performed by Reflex as Part of the Thrombotic Risk Reflex Panel (3017156)
Reflex Reason	Test Added (Code)
Specific findings within the Lupus Anticoagulant Reflex Panel	Refer to the Lupus Anticoagulant Reflex Panel Test Fact Sheet for information about the Lupus Anticoagulant Reflex Panel (3017009)

Test Interpretation

Sensitivity/Specificity

Varies

Results

Interpretive information, including the reference interval, is provided for each test component. Refer to the Example Reports on the ARUP Laboratory Test Directory for more information. For more information about anticoagulant neutralization in the lupus anticoagulant panel, refer to the Lupus Anticoagulant Reflex Panel Test Fact Sheet.

Limitations

Results should be interpreted within the context of a patient’s complete clinical picture.
The following factors may result in test interference or spurious results:
- Acute phase reactions due to pregnancy, malignancy, inflammatory or infectious states, or trauma
- Liver disease
- Anticoagulant medications in concentrations exceeding the capacity of neutralizing reagents (heparins, direct oral anticoagulants [DOACs])
- Warfarin effect
- Residual platelets (≥10,000 platelets/uL) in the plasma sample
- Specific factor antibodies directed against clotting factors involved in the intrinsic or common pathways.

Feedback