Acute Lymphoblastic Leukemia - ALL

Acute lymphoblastic leukemia (ALL) is an aggressive type of leukemia of either B- or T-lineage immature lymphoid cells. ALL is primarily a childhood disease (ALL represents 75-80% of all acute leukemias in children ) and follows a bimodal distribution; the first peak occurs between 3 and 5 years of age and the second in adults older than 50 years.  Prognosis can be inferred from age and white blood cell (WBC) count at diagnosis. Adults and those with high WBC counts typically have a poorer prognosis.  An initial ALL workup generally involves CBC testing, coagulation studies, liver function testing, and chemistry profiles; definitive diagnosis requires demonstration of ≥20% bone marrow lymphoblasts in bone marrow aspirate or biopsy.   Morphology, cytogenetics, and immunophenotyping allow for identification of recurrent genetic abnormalities that inform risk stratification, treatment planning, and monitoring.  

Tabs Content
Content Review: 
November 2019

Last Update: November 2019