Atherosclerotic Cardiovascular Disease Risk Markers

Atherosclerotic cardiovascular disease (ASCVD) involves the buildup of cholesterol plaque in arteries and includes acute coronary syndrome, peripheral arterial disease, and events such as myocardial infarction and stroke. It is a major cause of morbidity and mortality in the United States. Dyslipidemia, diabetes mellitus (DM), obesity, inactive lifestyle, hypertension, smoking, and family history are all risk factors for ASCVD. Assessment of a patient’s 10-year risk for having an ASCVD event is fundamental in establishing the need for cholesterol-lowering medication. Lipid testing including total cholesterol, low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglycerides has traditionally been part of the evaluation for ASCVD risk; such testing is also used for screening and monitoring. Nontraditional, novel markers like apolipoproteins, lipoprotein particles, and high-sensitivity C-reactive protein (hsCRP) are gaining recognition for their role in the evaluation of high-risk patients.

Tabs Content
Content Review: 
October 2018

Last Update: February 2019