Atherosclerotic Cardiovascular Disease Risk Markers

Atherosclerotic cardiovascular disease (ASCVD) involves the buildup of cholesterol plaque in arteries and includes acute coronary syndrome, peripheral arterial disease, and events such as myocardial infarction and stroke. ASCVD is a major cause of morbidity and mortality in the United States. Risk factors such as dyslipidemia, diabetes mellitus (DM), obesity, inactive lifestyle, hypertension, smoking, and family history inform ASCVD risk assessments. Understanding a patient’s 10-year ASCVD risk is fundamental in establishing appropriate medical management (eg, cholesterol-lowering medication). Traditional lipid tests for markers such as total cholesterol, low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglycerides are recommended for the evaluation of ASCVD risk; such testing is also used for screening and monitoring. Nontraditional, novel markers like apolipoproteins, lipoprotein particles, and high-sensitivity C-reactive protein (hsCRP) are gaining recognition for their role in the evaluation of high-risk patients.

Tabs Content
Content Review: 
October 2019

Last Update: October 2019