Sepsis is a severe illness characterized by a systemic, whole-body response to infection and is a frequent cause of morbidity and mortality in hospitalized patients. Sepsis is most common in older individuals and infants, and can be difficult to diagnose because of the highly variable presentation. Because there is no confirmatory diagnostic test, sepsis diagnosis requires clinical judgment based on evidence of infection and organ dysfunction. 

The clinical practice guideline issued by the Surviving Sepsis Campaign (SSC) emphasizes the importance of early identification and immediate management of infection, including obtaining cultures and measuring lactate as soon after patient presentation as possible. The SSC recently released a 1-hour bundle that combines the SSC’s previous 3-hour and 6-hour bundles and recommends beginning sepsis management and treatment immediately at the point of presentation. 

Tabs Content
Content Review: 
August 2018

Last Update: November 2018