Thrombotic Microangiopathies - TMA

Thrombotic microangiopathy (TMA) syndromes can be acquired or hereditary. Thrombotic thrombocytopenic purpura (TTP) and hemolytic uremic syndrome (HUS) are two prototypes of TMAs, although TMAs may occur secondarily to multiple other systemic disorders (eg, malignant hypertension, medications). These disorders are associated with hemolysis (anemia), thrombocytopenia, and renal dysfunction in adults and children. TTP should be distinguished from other TMA syndromes, as patients with ADAMTS13 deficiency are likely to respond to therapeutic plasma exchange (TPE) whereas those without ADAMTS13 severe deficiency require treatments other than TPE (Joly, 2016).

Tabs Content
Content Review: 
December 2017

Last Update: August 2018