Anemia of Chronic Disease - Anemia of Inflammation

Anemia of chronic disease (ACD), also known as anemia of inflammation (AI), is a functional anemia of iron-restricted erythropoiesis related to chronic diseases, such as infections, autoimmune diseases, cancer, and end-organ failure.   ACD/AI is the second most common form of anemia after iron deficiency anemia (IDA) and the most common form of anemia in hospitalized or critically ill patients.   Testing for ACD/AI includes standard blood parameter measurements, a peripheral blood smear, iron studies, testing to exclude other possible diagnoses, and in some cases, bone marrow biopsy.  ACD/AI testing should be interpreted in the appropriate clinical context.  Treatment for ACD/AI entails treatment of the underlying disease or disorder; however, this is often not feasible.  Iron therapy and erythropoiesis-stimulating agents may be used to alleviate anemia and thereby improve patient quality of life.   

Tabs Content
Content Review: 
March 2019

Last Update: June 2019