Celiac Disease

Celiac disease (CD), or gluten-sensitive enteropathy, is a nonallergic, autoimmune-mediated sensitivity to gluten or related proteins in genetically susceptible individuals.  Initial testing for CD typically includes assessment of the serum immunoglobulin A (IgA) level, followed by the appropriate tissue transglutaminase (tTG) antibody test (IgA or IgG, depending on whether or not the patient is IgA deficient).    Duodenal biopsy remains the gold standard for diagnostic confirmation of CD, and HLA-DQ2 and HLA-DQ8 genotyping may be essential in risk estimation or disease exclusion. CD risk varies among ethnicities and geographic regions, suggesting that environmental and/or lifestyle risk factors may play a role in disease etiology. 

Tabs Content
Content Review: 
December 2019

Last Update: December 2019