Colorectal Cancer

Colorectal cancer (CRC) is a leading cause of cancer death and the fourth most common form of cancer in the United States. In recent years, both CRC incidence and CRC-related mortality have decreased, which underscores the importance of continued advances in CRC early detection, diagnosis, and care.  Although sporadic colon cancers are more common, hereditary colon cancers are also frequent, and identification of these affects screening recommendations both for the individual and family members. CRC screening strategies rely on imaging, laboratory testing, or a combination of the two. Molecular testing of cancer tissue, including evaluation for microsatellite instability (MSI), is recommended to evaluate for Lynch syndrome (LS) risk and to inform prognosis. Monitoring of serum carcinoembryonic antigen (CEA) is recommended following resection of most CRCs to detect recurrence. Laboratory testing may also be used to determine whether particular treatments are likely to be effective.

Tabs Content
Content Review: 
December 2019

Last Update: January 2020