Lynch Syndrome - Hereditary Nonpolyposis Colorectal Cancer (HNPCC)

Colorectal cancer (CRC) exhibits the characteristics of familial clustering in ~10-15% of cases. The most common cause of hereditary CRC is Lynch syndrome (LS), also known as hereditary nonpolyposis colorectal cancer (HNPCC). LS is caused by a germline mutation in one of the genes within the DNA mismatch repair (MMR) system.

Tabs Content
Content Review: 
June 2017

Last Update: October 2019