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Disease Topics — Autoimmune hepatitis (AIH) is a chronic autoimmune liver disease (ALD) that is characterized by hypergammaglobulinemia. If diagnosed and treated promptly, patie Indications for Testing
Testing for AIH should be considered in all individuals who present with acute or chronic liver disease (including acute liver failure) or abnormal liver function tests (elevated aspartate aminotransferase [AST] a … Autoimmune Hepatitis Autoimmune …
Algorithm — A patient may have symptoms of liver disease or hepatitis without a clear cause. If the patient has elevated transaminases but all viral serologies are negative, more testing is needed.
Disease Topics — Hepatitis, or inflammation of the liver, may be caused by viral infection. Hepatitis A, B, C, D, and E viruses (HAV, HBV, HCV, HDV, and HEV) infect hepatocytes and cause acute or chronic hepatitis. Indications for Testing
Laboratory testing for viral hepatitis is appropriate for screening (eg, prenatal screening for HBV and HCV) or at new onset of symptoms such as jaundice, anorexia, or dark urine, or after a known or suspected exp … Viral Hepatitis Hepatitis, or inflammation of the liver, may be…
Disease Topics — Connective tissue or systemic autoimmune rheumatic diseases (SARDs) are characterized by autoantibodies that can affect tissues and organs throughout the body. Indications for Testing
The following SARDs may manifest with these indications: … Connective Tissue Diseases - Systemic Autoimmune Rheumatic Diseases Connective…
Disease Topics — There is a broad spectrum of laboratory tests used to evaluate liver function and liver damage. Colloquially, these are referred to as liver function tests, although they are not all direct measures of liver function. Indications for Testing
Testing may be ordered as part of a routine evaluation or to screen for and monitor liver disease (eg, viral or … liver-related diseases, refer to the ARUP Consult Viral Hepatitis , …
Disease Topics — Hepatocellular carcinoma (HCC) tumors are among the most common in the world, particularly in populations with chronic viral hepatitis, such as those of Asian or sub-Saharan African ancestry. Most occur in individuals with Key Points
HCC Surveillance Guidelines
The incidence of HCC is rising in many countries. HCC is associated with a low 5-year survival rate due to late-stage detection when disease is often advanced. … the world, particularly in populations with chronic viral hepatitis, such as…
Disease Topics — Primary sclerosing cholangitis (PSC) is a progressive autoimmune liver disease (ALD) that often leads to cirrhosis and may eventually require liver transplantation. Indications for Testing
PSC should be considered in patients with elevated alkaline phosphatase (ALP) and gamma-glutamyl transferase (GGT), symptoms of liver disease … PSC Primary sclerosing cholangitis (PSC) is a progressive autoimmune liver…
Disease Topics — Primary biliary cholangitis (PBC), previously referred to as primary biliary cirrhosis, is an autoimmune liver disorder characterized by chronic, progressive cholestatic disease. Indications for Testing
Laboratory testing for PBC is used to … previously referred to as primary biliary cirrhosis, is an autoimmune liver…
Disease Topics — Sjögren syndrome is an autoimmune disease characterized by lymphocytic infiltration of exocrine glands that results in dry eyes and dry mouth; other common symptoms include fatigue and joint pain. Criteria for Diagnosis
The American College of Rheumatology (ACR) and European League Against Rheumatism (EULAR) classification criteria for primary Sjögren syndrome … Sjögren Syndrome Sjögren syndrome is an autoimmune disease characterized by…
Disease Topics — Celiac disease (CD), or gluten-sensitive enteropathy, is a nonallergic, autoimmune-mediated sensitivity to gluten in genetically susceptible individuals. Initial testing for CD typically includes assessment of both serum immunoglobulin A (IgA Indications for Testing
Children and Adolescents
Chronic, unexplained gastroenterologic symptoms, poor growth, weight loss, delayed puberty, iron-deficiency anemia, and abnormal liver test results i … (CD), or gluten-sensitive enteropathy, is a nonallergic, autoimmune-mediated…