Sjögren Syndrome

Sjögren syndrome is an autoimmune disease characterized by lymphocytic infiltration of exocrine glands that results in dry eyes and dry mouth; other common symptoms include fatigue and joint pain.  The disease may affect as many as four million people in the United States and is one of the more prevalent systemic autoimmune rheumatic diseases (SARDs).  Primary Sjögren syndrome occurs alone or in conjunction with other systemic autoimmune disease (eg, rheumatoid arthritis or systemic lupus erythematosus [SLE]) or organ-specific autoimmune diseases (eg, thyroiditis or primary biliary cholangitis).  Although no laboratory test is specific for Sjögren syndrome, tests for antinuclear antibodies (ANAs), antibodies against Sjögren’s syndrome-related antigen A and B (anti-SSA [Ro], anti-SSB [La]), and rheumatoid factor (RF) may aid in the diagnostic evaluation of Sjögren syndrome. 

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Last Update: November 2018