Mast Cell Disorders

Mast cell disorders (MCDs) are a diverse group of conditions characterized by inappropriate mast cell (MC) activation and/or the proliferation and accumulation of abnormal MCs throughout the body.   These conditions range in severity from benign, nonclonal disorders to malignant clonal diseases that rapidly progress and may involve the skin (eg, cutaneous mastocytosis [CM]) or extracutaneous organs (eg, systemic mastocytosis [SM]). Symptoms result from the release of MC mediators (eg, tryptase and histamine) and/or end organ damage.  The diagnostic approach depends on the type of MCD. Laboratory testing involves measuring serum tryptase and performing KIT gene mutational analysis on bone marrow and/or peripheral blood.

Tabs Content
Content Review: 
January 2019

Last Update: March 2019